A review of recent advances in ab initio protein folding by the Folding@home project
نویسنده
چکیده
The Folding@home project harnesses a volunteer distributed computing network to perform ab initio molecular simulations of protein folding. Thanks to engineering innovations like a Graphical Processing Unit (GPU) client for running simulations, Folding@home is able to harness over 6.1 petaFLOPS of processing power, allowing it to simulate longer and more complex protein folding mechanisms than ever before. This paper will review the background science underlying the Folding@home project with a focus on the GPU client and its use in folding NTL9, the slowest-folding protein ever simulated ab initio with fidelity to experimental results.
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